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Treatment with caspase-1 inhibitor decreased gene expression of ( A ) IL-1β, ( B ) GSDMD and protein expression of ( C ) IL-1β, ( D ) GSDMD in hyperoxia-exposed <t>endothelial</t> cells. ( E ) Representative western blots of IL-1β and of GSDMD in the endothelial cells. In addition, caspase-1 inhibitor also reduced gene expression of ( F ) IL-1β ( G ) GSDMD and protein expression of ( H ) IL-1β, ( I ) GSDMD in hyperoxia-exposed smooth muscle cells. ( J ) Representative western blots of IL-1β and of GSDMD in the smooth muscle cells. n = 4–5/group, data are mean ± SD, two-way ANOVA with Tukey’s multiple comparisons test. * P <0.05 ** P <0.01, *** P <0.001; **** P <0.0001. HYP, hyperoxia; PL, placebo; RA, room air; VX-765, caspase-1 Inhibitor.
Human Umbilical Artery Endothelial Cells, supplied by Cell Applications Inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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arterial endothelial cells  (PromoCell)
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Treatment with caspase-1 inhibitor decreased gene expression of ( A ) IL-1β, ( B ) GSDMD and protein expression of ( C ) IL-1β, ( D ) GSDMD in hyperoxia-exposed <t>endothelial</t> cells. ( E ) Representative western blots of IL-1β and of GSDMD in the endothelial cells. In addition, caspase-1 inhibitor also reduced gene expression of ( F ) IL-1β ( G ) GSDMD and protein expression of ( H ) IL-1β, ( I ) GSDMD in hyperoxia-exposed smooth muscle cells. ( J ) Representative western blots of IL-1β and of GSDMD in the smooth muscle cells. n = 4–5/group, data are mean ± SD, two-way ANOVA with Tukey’s multiple comparisons test. * P <0.05 ** P <0.01, *** P <0.001; **** P <0.0001. HYP, hyperoxia; PL, placebo; RA, room air; VX-765, caspase-1 Inhibitor.
Arterial Endothelial Cells, supplied by PromoCell, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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arterial endothelial cells - by Bioz Stars, 2026-02
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huaecs  (Cell Applications Inc)
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Treatment with caspase-1 inhibitor decreased gene expression of ( A ) IL-1β, ( B ) GSDMD and protein expression of ( C ) IL-1β, ( D ) GSDMD in hyperoxia-exposed <t>endothelial</t> cells. ( E ) Representative western blots of IL-1β and of GSDMD in the endothelial cells. In addition, caspase-1 inhibitor also reduced gene expression of ( F ) IL-1β ( G ) GSDMD and protein expression of ( H ) IL-1β, ( I ) GSDMD in hyperoxia-exposed smooth muscle cells. ( J ) Representative western blots of IL-1β and of GSDMD in the smooth muscle cells. n = 4–5/group, data are mean ± SD, two-way ANOVA with Tukey’s multiple comparisons test. * P <0.05 ** P <0.01, *** P <0.001; **** P <0.0001. HYP, hyperoxia; PL, placebo; RA, room air; VX-765, caspase-1 Inhibitor.
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https://www.bioz.com/result/huaecs/product/Cell Applications Inc
Average 93 stars, based on 1 article reviews
huaecs - by Bioz Stars, 2026-02
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huaecs  (PromoCell)
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Treatment with caspase-1 inhibitor decreased gene expression of ( A ) IL-1β, ( B ) GSDMD and protein expression of ( C ) IL-1β, ( D ) GSDMD in hyperoxia-exposed <t>endothelial</t> cells. ( E ) Representative western blots of IL-1β and of GSDMD in the endothelial cells. In addition, caspase-1 inhibitor also reduced gene expression of ( F ) IL-1β ( G ) GSDMD and protein expression of ( H ) IL-1β, ( I ) GSDMD in hyperoxia-exposed smooth muscle cells. ( J ) Representative western blots of IL-1β and of GSDMD in the smooth muscle cells. n = 4–5/group, data are mean ± SD, two-way ANOVA with Tukey’s multiple comparisons test. * P <0.05 ** P <0.01, *** P <0.001; **** P <0.0001. HYP, hyperoxia; PL, placebo; RA, room air; VX-765, caspase-1 Inhibitor.
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https://www.bioz.com/result/huaecs/product/PromoCell
Average 94 stars, based on 1 article reviews
huaecs - by Bioz Stars, 2026-02
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n a human umbilical arterial endothelial cells huaecs promocell  (PromoCell)
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Treatment with caspase-1 inhibitor decreased gene expression of ( A ) IL-1β, ( B ) GSDMD and protein expression of ( C ) IL-1β, ( D ) GSDMD in hyperoxia-exposed <t>endothelial</t> cells. ( E ) Representative western blots of IL-1β and of GSDMD in the endothelial cells. In addition, caspase-1 inhibitor also reduced gene expression of ( F ) IL-1β ( G ) GSDMD and protein expression of ( H ) IL-1β, ( I ) GSDMD in hyperoxia-exposed smooth muscle cells. ( J ) Representative western blots of IL-1β and of GSDMD in the smooth muscle cells. n = 4–5/group, data are mean ± SD, two-way ANOVA with Tukey’s multiple comparisons test. * P <0.05 ** P <0.01, *** P <0.001; **** P <0.0001. HYP, hyperoxia; PL, placebo; RA, room air; VX-765, caspase-1 Inhibitor.
N A Human Umbilical Arterial Endothelial Cells Huaecs Promocell, supplied by PromoCell, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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frozen human umbilical arterial endothelial cells  (Cell Applications Inc)
93
Cell Applications Inc frozen human umbilical arterial endothelial cells
Proposed pathway for the effects of COMP-4 in the human arterial <t>endothelial</t> cell.
Frozen Human Umbilical Arterial Endothelial Cells, supplied by Cell Applications Inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Treatment with caspase-1 inhibitor decreased gene expression of ( A ) IL-1β, ( B ) GSDMD and protein expression of ( C ) IL-1β, ( D ) GSDMD in hyperoxia-exposed endothelial cells. ( E ) Representative western blots of IL-1β and of GSDMD in the endothelial cells. In addition, caspase-1 inhibitor also reduced gene expression of ( F ) IL-1β ( G ) GSDMD and protein expression of ( H ) IL-1β, ( I ) GSDMD in hyperoxia-exposed smooth muscle cells. ( J ) Representative western blots of IL-1β and of GSDMD in the smooth muscle cells. n = 4–5/group, data are mean ± SD, two-way ANOVA with Tukey’s multiple comparisons test. * P <0.05 ** P <0.01, *** P <0.001; **** P <0.0001. HYP, hyperoxia; PL, placebo; RA, room air; VX-765, caspase-1 Inhibitor.

Journal: Clinical Science (London, England : 1979)

Article Title: Caspase-1 inhibition mitigates neonatal hyperoxia-induced vascular and cardiopulmonary inflammation in neonatal rats

doi: 10.1042/CS20242275

Figure Lengend Snippet: Treatment with caspase-1 inhibitor decreased gene expression of ( A ) IL-1β, ( B ) GSDMD and protein expression of ( C ) IL-1β, ( D ) GSDMD in hyperoxia-exposed endothelial cells. ( E ) Representative western blots of IL-1β and of GSDMD in the endothelial cells. In addition, caspase-1 inhibitor also reduced gene expression of ( F ) IL-1β ( G ) GSDMD and protein expression of ( H ) IL-1β, ( I ) GSDMD in hyperoxia-exposed smooth muscle cells. ( J ) Representative western blots of IL-1β and of GSDMD in the smooth muscle cells. n = 4–5/group, data are mean ± SD, two-way ANOVA with Tukey’s multiple comparisons test. * P <0.05 ** P <0.01, *** P <0.001; **** P <0.0001. HYP, hyperoxia; PL, placebo; RA, room air; VX-765, caspase-1 Inhibitor.

Article Snippet: Human Umbilical Artery Endothelial Cells, HUAECs (Cat# 202–05n, Cell Applications, San Diego, CA) were cultured in a human MesoEndo growth medium (Cat# 212–500, Cell Applications, San Diego, CA).

Techniques: Gene Expression, Expressing, Western Blot

Proposed pathway for the effects of COMP-4 in the human arterial endothelial cell.

Journal: PLOS ONE

Article Title: Nutraceutical COMP-4 confers protection against endothelial dysfunction through the eNOS/iNOS-NO-cGMP pathway

doi: 10.1371/journal.pone.0316798

Figure Lengend Snippet: Proposed pathway for the effects of COMP-4 in the human arterial endothelial cell.

Article Snippet: Frozen human umbilical arterial endothelial cells (HUAEC, cat# 202-05n, Cell Applications, Inc., San Diego, CA) were thawed in a 37°C water bath.

Techniques: